Introduction:

Drug-Induced Lichen Planus is a rare skin condition triggered by the use of certain medications. It is characterized by itchy, flat-topped, and polygonal papules on the skin, often accompanied by oral or genital involvement. In this article, we will discuss the causes, symptoms, diagnosis, and treatment options for drug-induced lichen planus.

Causes:

Drug-Induced Lichen Planus is primarily caused by the use of specific medications, including:

• Antihypertensive drugs: Such as beta-blockers and thiazide diuretics.
• Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Like ibuprofen and naproxen.
• Antimalarial medications: Such as hydroxychloroquine and chloroquine.
• Gold salts: Used in the treatment of rheumatoid arthritis.
• Certain antibiotics: Including penicillin and tetracycline.

Symptoms:

The symptoms of drug-induced lichen planus may include:

• Skin rash: Characterized by itchy, flat-topped, and polygonal papules.
• Oral involvement: White, lacy lesions in the mouth or on the tongue.
• Genital involvement: Similar lesions may appear in the genital area.
• Itching: Intense itching, especially on the affected skin.

Diagnosis:

Diagnosing drug-induced lichen planus involves several steps, including:

• Clinical evaluation: A thorough medical history and physical examination.
• Medication history: Identifying the medication responsible for the condition.
• Skin biopsy: A sample of affected skin may be examined under a microscope to confirm the diagnosis.

Treatment:

The primary treatment for drug-induced lichen planus is discontinuing the causative medication. Additional treatment options may include:

• Topical corticosteroids: These creams or ointments can help reduce itching and inflammation.
• Oral antihistamines: These may be prescribed to relieve itching.
• Immunosuppressive drugs: In severe cases, medications like cyclosporine or methotrexate may be prescribed.
• Phototherapy: Exposure to ultraviolet (UV) light under medical supervision may help improve skin lesions.

Prevention:

Preventing drug-induced lichen planus involves careful monitoring by healthcare providers when prescribing medications known to be associated with this condition. Patients should be educated about potential side effects and encouraged to report any unusual symptoms promptly.

Conclusion:

Drug-Induced Lichen Planus is a rare but bothersome skin condition triggered by exposure to specific medications. Early recognition, diagnosis, and discontinuation of the causative drug, along with appropriate medical treatment, are essential for managing this condition effectively and preventing complications.

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